Costus root extract improves testicular toxicity of Bisphenol A in adult male albino rats: histopathological, ultrastructural and biochemical studies

Abstract Background Bisphenol A (BPA) causes environmental pollution and is used as a natural antioxidant to protect against chemical side-effects. Costus well-known medicinal plant containing several biologically active compounds. We investigated the protective effects of costus extract toxic BPA in rat testes. Results Biochemical immunohistochemical investigations revealed that bisphenol reduced activity enzymes plasma testosterone levels significantly increased P53. Co-administration root with improved depletion enzymes, returned normal levels, P53 alternations. Histological ultrastructural examinations showed body testicular weights, degeneration seminiferous tubule germ cells, use attenuated these effects. Conclusions protects testes BPA.